Cloning and sequence analysis of gene oipA encoding an outer membrane protein of human Helicobacter pylori
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چکیده
منابع مشابه
Cloning and Sequence Analysis of Gene Encoding OipA from Iranian Clinical Helicobacter pylori
Background: Outer inflammatory protein A (OipA) is one of the important adhesins of H. pylori and a valuable candidate for vaccine development. Its gene is under "on-off" switch status which correlates with OipA protein expression. Objectives: We aimed to obtain a recombinant OipA clone (with "on" status) from an Iranian clinical isolate. Materials and Methods: A clinical H. pylori-isolate demo...
متن کامل(oipA) of Helicobacter pylori
MICROBIOLOGY. For the article ‘‘A Mr 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori’’ by Yoshio Yamaoka, Dong H. Kwon, and David Y. Graham, which appeared in number 13, June, 20, 2000, of Proc. Natl. Acad. Sci. USA (97, 7533–7538), the authors note the following correction. The sequence of the HP0638 gene was incorrect as published. The sequence published was 59-GCT...
متن کاملHelicobacter pylori Outer Membrane Protein-Related Pathogenesis
Helicobacter pylori colonizes the human stomach and induces inflammation, and in some cases persistent infection can result in gastric cancer. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and outer membrane proteins (OMPs) play a pivotal role in binding to human cells. Some OMP interaction molecules are known in H. pylori, and their associated host ...
متن کاملcytotoxicity effect of recombinant outer membrane inflammatory protein (oipa) of helicobacter pylori on a breast cancer cell line
objective: breast cancer is one of the leading causes of death in women worldwide. conventional treatments use cytotoxic drugs which have high numbers of side effects. currently pharmacologists are searching for novel drugs with fewer side effects and maximum efficiency as breast cancer treatment. the aim of the current study is to clarify the cytotoxicity effect of the recombinant outer membra...
متن کاملimmunological detection of 34 kda outer membrane protein as a functional form of oipa in clinical isolates of helicobacter pylori.
background and objective: an outer membrane protein (omp) of helicobacter pylori namely oipa, is an important vir- ulence factor associated with peptic ulcer and gastric cancer risks. the purpose of this study was to isolate the 34 kda omp of h. pylori and evaluate its immunogenicity in experimental animals for rapid detection of more virulent h. pylori isolates. material and methods: sarcosine...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2004
ISSN: 1007-9327
DOI: 10.3748/wjg.v10.i21.3205